Table 4.
Clinical trials involving the combination with epigenetic modulators and immunotherapy.
| Immune Checkpoint blockade + Epigenetic modulator | |||
|---|---|---|---|
| Clinical trial | Condition | Phase | Intervention |
| NCT02395627 | Breast | Phase II | Pembrolizumab+Tamoxifen+Vorinostat |
| NCT02538510 | Head&neck | Phase I/II | Pembrolizumab+Vorinostat |
| NCT02437136 | NSCLC/Melanoma | Phase I/II | Pembrolizumab+Entinostat |
| NCT01928576 | NSCLC | Phase II | Azacitidine –> Nivolumab Azacitidine+Entinostat –> Nivolumab |
NSCLC = non-small cell lung cancer;