Figure 3.
Conservation of binding between Drosophila dFOXO and mouse FOXO, human FOXO and mouse FOXO, and among all species examined. (A) Venn diagram representing overlap between direct binding by dFOXO in Drosophila and mouse FOXO (P = 2.98 × 10−12, Fisher's exact test; all unique mouse–Drosophila orthologs were used as background; 9314 genes). (B) Venn diagram representing overlap between direct binding by FOXO in mouse and human FOXO (P = not significant, Fisher's exact test; all unique mouse–human orthologs were used as background; 16754 genes). (C) PANTHER Biological Process and (D) PANTHER Pathway analysis of the 1053 FOXO direct target genes conserved between mouse and human. (E) Overlap among FOXO targets in Caenorhabditis elegans, Drosophila, mouse, and human. The overlap (dark red) is statistically significant (P = 0.02, Monte Carlo simulation; all genes with orthologs across these species were used as background, 5706 genes). (F) Examples of conserved FOXO‐bound genes in C. elegans, Drosophila, mouse, and human.