Figure 4.
A subset of FOXO targets changes with age. (A) Overlap between Caenorhabditis elegans DAF‐16 targets and genes that are either upregulated or downregulated with age in this species. The overlap is shown in the upper left (Venn diagram, P = 2.76 × 10−6, Fisher's exact test; background is all unique genes on the worm aging microarray, 11706 genes), and the expression profile of the overlapping targets during aging is shown on the right. (B) The same arrangement as in (A) showing comparisons between mouse genes that change with age and FOXO binding in the mouse (P = 0.02; Fisher's exact test; background is all unique genes on the mouse aging microarray, 8400 genes). (C‐D) Same as (A), depicting overlap between conserved FOXO/DAF‐16 binding at C. elegans genes (P = 0.87; Fisher's exact test; background is all unique genes on the C. elegans aging microarray and with mouse–C. elegans orthologs, 3407 genes) and mouse genes (P = 0.28, Fisher's exact test; background is all unique genes on the mouse aging microarray and with mouse–C. elegans orthologs, 2694 genes) that change with age.