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. 2016 Jul 6;7:84. doi: 10.3389/fendo.2016.00084

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Copyright © 2016 Herroon, Diedrich and Podgorski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of tumor cell invasion toward adipocytes with FABP4 inhibitor and Atglistatin. (A,B) Invasion under control conditions at 4 h (A) and 70 h (B). Adipocytes (BODIPY, green); Tumor cells (DsRed; red). (C) Invasion in the presence of 10 μM Atglistatin, (D) 1 μM FABP4 inhibitor, (E) Invasion in the presence of FABP4 inhibitor and Atglistatin in combination. Green arrow (X), red arrow (Y), and blue arrow (Z) indicate orientation of the spheroid in 3D space (F) Quantification of the average distance between PC3 cells and adipocytes under all experimental conditions. Distances between PC3 and adipocyte layer (in micrometers) were measured using the Zeiss LSM Image Browser software. Data were analyzed using GraphPad Prizm and shown as the mean of three independent experiments ± SD (relative to baseline invasion at 4 h). *p < 0.05 and ***p < 0.001 are considered statistically significant.