Table 2.
Effect of treatments on spontaneous locomotor activity in mice
| Treatment (mg/kg) | Distance traveled (cm) | |
|---|---|---|
| (A) | saline + saline | 705.0 ± 39.07 |
| traxoprodil 10 + saline | 629.1 ± 79.29 | |
| imipramine 15 + saline | 492.3 ± 57.11 | |
| traxoprodil 10 + imipramine 15 | 638.3 ± 57.77 | |
| (B) | saline + saline | 705.0 ± 39.07 |
| traxoprodil 10 + saline | 629.1 ± 79.29 | |
| fluoxetine 5 + saline | 667.8 ± 111.1 | |
| traxoprodil 10 + fluoxetine 5 | 728.4 ± 96.91 | |
| (C) | saline + saline | 815.6 ± 63.98 |
| traxoprodil 10 + saline | 986.8 ± 278.5 | |
| escitalopram 2 + saline | 957.1 ± 174.1 | |
| traxoprodil 10 + escitalopram 2 | 1096 ± 107.6 | |
| (D) | saline + saline | 705.0 ± 39.07 |
| traxoprodil 10 + saline | 629.1 ± 79.29 | |
| reboxetine 2.5 + saline | 566.1 ± 54.75 | |
| traxoprodil 10 + reboxetine 2.5 | 636.0 ± 100.8 | |
| (E) | saline + saline | 983.8 ± 224.3 |
| traxoprodil 20 + saline | 731.1 ± 145.1 | |
| p-CPA 200 + saline | 656.4 ± 107.4 | |
| traxoprodil 20 + p-CPA 200 | 716.0 ± 70.99 | |
| (F) | saline + saline | 815.6 ± 63.98 |
| traxoprodil 20 + saline | 687.5 ± 71.45 | |
| WAY 0.1 + saline | 639.0 ± 59.16 | |
| traxoprodil 20 + WAY 0.1 | 615.8 ± 53.48 | |
| (G) | saline + saline | 815.6 ± 63.98 |
| traxoprodil 20 + saline | 687.5 ± 71.45 | |
| ritanserin 4 + saline | 607.5 ± 79.78 | |
| traxoprodil 20 + ritanserin 4 | 558.9 ± 53.11 |
Antidepressants, traxoprodil and saline were administered i.p. 60 min before the experiment. p-CPA was administered i.p. once daily over three consecutive days. Distance traveled was recorded between the 2nd and the 6th min of the test. Each experimental group consisted of 8 animals. Data are presented as the means ± SEM. The results were considered statistically significant if p < 0.05 (two-way ANOVA followed by Bonferoni’s post hoc test)