Table 4.

Effect of antidepressants on the concentrations of traxoprodil in mouse brain

	Treatment (mg/kg)	Traxoprodil concentration in brain (ng/g)
	traxoprodil 10 + saline	76.40 ± 13.51
(A)	traxoprodil 10 + imipramine 15	119.2 ± 22.52
(B)	traxoprodil 10 + fluoxetine 5	150.6 ± 10.34***
(C)	traxoprodil 10 + escitalopram 2	248.9 ± 49.25**

Antidepressants and traxoprodil were administered ip 60 min before decapitation. Each experimental group consisted of 7–8 animals. Results are presented as mean values ± SEM. **p < 0.01; ***p < 0.001 compared with the control group (Student’s t-test)