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. 2016 Jun 9;20:363–374. doi: 10.1007/s40291-016-0204-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Expression of FGFR1–4 protein sorted by head and neck cancer site and HPV status. FGFR1–4 protein expression was determined immunohistochemically in a cohort of oral cavity squamous cell carcinoma (n = 512) and oropharyngeal squamous cell carcinoma (n = 439) from the University Medical Center Utrecht and University Medical Center Groningen. FGFR1–4 proteins were high expressed in 39–64 % of oral cavity squamous cell carcinoma and 63–79 % of oropharyngeal squamous cell carcinoma. High protein expression was more common in oropharyngeal squamous cell carcinoma than oral cavity squamous cell carcinoma for all four FGFR family members (p = 0.008). FGFR1 protein was high expressed much more frequently in HPV-negative than in HPV-positive oropharyngeal squamous cell carcinoma (82 vs. 65 %; p = 0.008). FGFR fibroblast growth factor receptor, HPV human papillomavirus, OPSCC oropharyngeal squamous cell carcinoma, OCSCC oral cavity squamous cell carcinoma