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MiR-124 regulates TNF-α production at a minimum of two levels. Cholinergic agonist nicotine and LPS both can induce miR-124, which can regulate TNF-α production at a minimum of two levels, controlling the maturation at the pro-TNF-α level by targeting TACE (Cell Res 2013; 23: 1270–83) and promoting protein degradation at the TNF-α level by targeting USP2 and USP14.
