TABLE 2.

NHP clinical score, bacterial loads, and necropsy report

NHP group	Days postinfection	Bacterial loads in blood/organs	Clinical score	Necropsy report
Control	3–4	Blood, 0–2,500 CFU/ml; lung, 2.22 × 107–1.06 × 109 CFU/g; liver, 8.16 × 106–1.69 × 107 CFU/g; spleen, 2.13 × 106–4.47 × 106 CFU/g; Hilar lymph node, 1.12 × 109–1.26 × 109 CFU/node; submandibular lymph node, 2.0 × 105–2.33 × 105 CFU/node	≥8	External, thin, pale, dehydrated, and scruffy coat; respiratory, frothy serous discharge, hyperinflated with hemorrhagic frothy fluid (∼50 ml); lymphatic, enlarged submandibular node; spleen, firm and enlarged; liver, firm, enlarged, and rounded edges; locomotion, lethargic; body cavities, serous hemorrhagic fluid in thorax (∼50 ml)
Immunized	82	Negative for all organs; blood samples were negative for bacteria as early as day 3 postinfection	0	Normal