TABLE 3.

Principal component analysis of serum cytokine concentrations differentiating acute iNTS disease and convalescence^a

Cytokine	Analysis resultb
	PC1iNTS	PC2iNTS
LTA	0.94	−0.15
CSF1	0.92	−0.03
NGF	0.88	0
IL-3	0.85	0.1
CCL7	0.83	−0.03
LIF	0.83	−0.06
IFNα2	0.81	0
IL-2Ra	0.81	0.07
KITLG	0.81	0.1
IL-12p40	0.78	0.16
IL-18	0.77	0.07
CXCL9	0.72	0.1
CCL27	0.65	0.06
HGF	0.54	0.43
CXCL12	0.5	0.33
IL-1Ra	0.03	0.88
IL-6	0.06	0.85
CSF3	−0.05	0.77
IL-10	0.13	0.72
CXCL10	0.07	0.7
IL-15	−0.02	0.68
IL-8	0.24	0.6
CLEC11A	0.11	0.5
MIF	0.23	0.34
PDGFβ	−0.12	−0.3
IL-5	0.04	0.01
IL-1α	0.18	0.33
Eigenvalue	10.26	5.62
Proportion variance	0.38	0.21

^aMeasurements of 27 cytokines in 146 participant samples (73 matched acute- and convalescent-phase sample pairs) are included in the analysis.

^bFor each PC, the factor loading of each cytokine included in the analysis is displayed. Factor loadings represent the correlation between each cytokine and a principal component, varying between −1 and +1. The larger the absolute value of a given factor loading, the greater importance of that cytokine to the principal component. We define influential cytokines for a given principal component as having a factor loading of >0.4 or <−0.4. Cytokines with loadings in excess of ±0.4 account for at least 16% of the variance in the principal component. Influential cytokines for each principal component are displayed in boldface.