TABLE 4.

Principal component analysis of serum cytokine concentrations in acute iNTS disease differentiating fatal and nonfatal diseases^a

Cytokine	Analysis resultb
	PC1mortality	PC2mortality
LIF	0.97	−0.16
IL-18	0.90	−0.03
IL-3	0.90	0.08
IFNα2	0.89	0.00
CCL7	0.84	0.03
KITLG	0.79	0.12
CSF1	0.79	−0.05
CXCL12	0.61	0.35
IL-1α	0.45	0.40
IL-1Ra	−0.01	0.94
IL-8	−0.01	0.85
HGF	0.41	0.53
Eigenvalue	6.37	2.56
Proportion variance	0.53	0.21

^aMeasurements of 12 cytokines in 108 participant samples are included in the analysis.

^bFor each PC, the factor loading of each cytokine included in the analysis is displayed. Factor loadings represent the correlation between each cytokine and a principal component, varying between −1 and +1. The larger the absolute value of a given factor loading, the greater importance of that cytokine to the principal component. We define influential cytokines for a given principal component as having a factor loading of >0.4 or <−0.4. Cytokines with loadings in excess of ±0.4 account for at least 16% of the variance in the principal component. Influential cytokines for each principal component are displayed in boldface.