FIG 4.

S. sonnei LPS-specific ASC counts in oral live S. sonnei vaccine candidate WRSS1-immunized vaccinees and control volunteers after wild-type S. sonnei 53G challenge. IgA, IgG, and IgM ASC counts (GMN ± SE) were determined on study days 0, 7, and 9 for naive controls (n = 10) and on study days 0 (60), 7 (67), and 9 (69) for WRSS1-immunized vaccinees (n = 10) after 53G challenge. Ten vaccinees were subdivided into WRSS1 shedders (WS) (n = 6) and WRSS1 nonshedders (WNS) (n = 4). Within each group, 53G shedders (53G S) and 53G nonshedders (53G NS) are represented as dark spotted bars and light spotted bars, respectively.