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. 2016 Jul 6;6:29121. doi: 10.1038/srep29121

Figure 4. miR-1 depressed the secretion of BDNF.

Figure 4

Primary SCs (A) and RSC96 SCs (B) were transfected with miR-1 mimic (miR-1), miR-1 inhibitor (Anti-miR-1), mimic control (miR Con), or inhibitor control (Anti-miR Con), respectively. The BDNF secretion from both primary SCs and RSC96 SCs transfected with miR-1 mimic was significantly decreased, while the BDNF secretion from both primary SCs and RSC96 SCs transfected with miR-1 inhibitor was significantly increased, as compared to that from both primary SCs and RSC96 SCs transfected with control. Histogram (C) showing that miR-1-induced reduction of BDNF secretion was rescued by co-transfection with miR-1 mimic plus BDNF 3′-UTR plasmid. **p < 0.01, *p < 0.05.