Table 2. Clinical information of the patients subjected to temporal analysis and summary statistics of disease progression.

Patient ID	Figure ID	Type	Stage	Sage	Sex	Activating mutation	Initial response to EGFR-TKI	Prior treatment	ctDNA before EGFR-TKI	Last data point (1)	PD point (1)	IP point (1)	IP from PD (2)	Solitary peak (1)
1	2A	type I	IIIA	77	F	L858R	PR	surgery/chemotherapy	+	1115	659	659	0	−
2	S3A	type I	IV	39	F	exon 19 deletion	PR	curative radiation/chemotherapy	+	437	372	308	−64	112 (exon 19 deletion)
3	S3B	type I	IV	80	M	L858R	PR	none	+	440	296	347	51	−
4	S3C	type I	IV	62	M	exon 19 deletion	PR	none	+	228	180	129	−51	−
5	2B	type I	IV	69	F	L858R	PR	none	+	475	383	441	58	336 (T790M)
6	S3D	type I	IV	63	M	exon 19 deletion	PR	curative surgery	+	659	303	385	82	−
7	S3E	type I	IV	68	F	exon 19 deletion	PR	none	+	229	172	171	−1	−
8	S3F	type I	IIIB	39	F	exon 19 deletion	SD	curative surgery	−	718	159	252	93	−
9	3	type I	IV	37	M	exon 19 deletion	PR	none	+	1099	339	315	−24	−
10	S3G	type I	IV	73	F	L858R	PR	local radiation	+	865	325	360	35	143 (T790M)
11	2C	type I	IV	78	F	exon 19 deletion	SD	none	−	563	299	215	−84	−
12	2D	type II	IV	60	F	exon 19 deletion	PR	chemotherapy	+	434	336	161	−175	−
13	2E	type II	IIIA	66	F	L858R	NE	none	+	283	238	119	−119	−
14	2F	type II	IV	59	M	exon 19 deletion	PR	none	+	518	456	152	−304	−
15	S3H	type II	IIIB	56	F	L861Q	PR	none	+	761	335	102	−233	−
16	−	type III	IIIA	53	F	exon 19 deletion	PR	surgery/chemotherapy	−	700	558	n/a	n/a	−
17	−	type III	IV	73	F	L858R	NE	surgery/local radiation	+	75	57	n/a	n/a	−
18	−	type III	IV	61	F	exon 19 deletion	PR	none	−	489	375	n/a	n/a	−
19	−	type III	IV	49	M	L858R	PR	local radiation	+	560	202	n/a	n/a	−
20	−	type III	IV	49	M	exon 19 deletion	CR	surgery	−	874	838	n/a	n/a	−
21	−	type III	IV	72	M	L858R	PR	surgery radiataion	+	796	421	n/a	n/a	−
22	S4A	type III	IV	40	F	exon 19 deletion	PR	none	+	780	530	n/a	n/a	−
23	S4B	type III	IV	62	F	exon 19 deletion	PR	curative radiation/chemotherapy	−	667	350	n/a	n/a	−
24	−	type III	IV	74	M	L858R	PR	none	n/a	215	196	n/a	n/a	−
25	−	type III	IV	41	F	L858R	NE	curative surgery/chmotherapy	n/a	1075	591	n/a	n/a	−
26	−	type III	IV	73	F	exon 19 deletion	PR	none	−	554	290	n/a	n/a	−
27	−	type III	IV	54	F	L858R	PR	none	+	303	290	n/a	n/a	−
28	S4C	type III	IV	71	F	exon 19 deletion	PR	none	+	334	334	n/a	n/a	110 (exon 19 deletion/T790M)

(1) Days counted from initiation of EGFR-TKI. (2) Days counted from PD point to IP point. n/a, data not available or not applicable.