Figure 1. Administration of ovine anti-HA pAbs protects against subsequent lethal influenza infection.

Mice were prophylactically administered (25 mg/kg in 500 μL) ovine anti-HA pAbs (a), control pAbs (b) or PBS (c) via the intraperitoneal route. Twenty-four hours later mice were challenged with 500 TCID₅₀ (32 μL) PR8 influenza. The mice were closely monitored for weight loss (a–c) and euthanized according to predetermined humane endpoints (indicated by arrowheads). Data is presented as the weight loss of individual mice from infection day (n = 5). Corresponding survival curves (d) were analysed using the Mantel-Cox test to compare anti-HA treated to PBS treated and control treated mice. Significance is denoted as thus: ** = P < 0.01.