Figure 2. Ovine anti-HA pAb can treat established influenza infection.

Mice were intranasally infected with 500 TCID₅₀ (32 uL) PR8 influenza. Forty-eight hours later mice were administered anti-HA pAbs (25 mg/kg) via intraperitoneal injection (a), or intranasal administration (b). Control groups were intraperitoneally (c) or intranasally (d) administered control pAb. The mice were closely monitored for weight loss (a–d) and euthanized according to predetermined humane endpoints (indicated by arrowheads). Data is presented as weight loss of individual mice from infection day (n = 5). Survival curves (e) of treated groups were compared to control groups using the Mantel-Cox test. Significance is denoted as thus: * = P < 0.05.