Skip to main content
. 2016 Jul 6;6:28956. doi: 10.1038/srep28956

Figure 6. Caspase-1 and IL-1β double staining in the spinal dorsal horn of mice chronically treated with DMSO or curcumin (120 mg/kg) on day 7 after sham or SNI surgery.

Figure 6

The sham surgery induced a weak caspase-1-IR in the ipsilateral spinal dorsal horn (A,B). The changes in the caspase-1-IR were not observed in the sham group after intraperitoneal repeated curcumin (120 mg/kg) administration (A,B). After SNI surgery, increased caspase-1-IR was detected ipsilaterally to the lesion of the spinal dorsal horn, and many of the IL-1β-IR was co-labelled with caspase-1-IRs (C,C’). The intraperitoneal administration of curcumin inhibited the expression of caspase-1-IR in the ipsilateral spinal dorsal horn after SNI (D). (E) Intensity of caspase-1 staining in the superficial dorsal horn (laminae I–III). **p < 0.01, compared with the Sham + DMSO group; #p < 0.05 compared with the SNI + DMSO group; one-way ANOVA followed by Bonferroni post hoc test; n = 3–4 per group. (F) Number of IL-1β+/caspase-1+ double-labelled cells in the superficial dorsal horn (laminae I–III). **p < 0.01, compared with the Sham + DMSO group; ##p < 0.01 compared with the SNI + DMSO group; one-way ANOVA followed by Bonferroni post hoc test; n = 3–4 per group. Scale bar = 50 μm.

HHS Vulnerability Disclosure