Table 3.

Costs and outcomes of each pathway (in screening population of 698 500 pregnant women), using national data

Testing strategy	Screening				NIPT (£250)			Invasive testing			Total costs (£000)	DS positive		IPD related miscarriage (No)
	No	Test positive	£000		No	£000		Direct No	After NIPT No	£000		NIPT or IPD	Confirmed by IPD
Current	462 407	10 635	13 312		0	0		5743	0	3733	17 045	577	577	29
NIPT ≥1/1000	462 407	45 316	13 312		32 160	8940		2127	297	1576	23 829	833	732	12
NIPT ≥1/500	462 407	26 357	13 312		18 795	5225		2127	282	1566	20 103	814	719	12
NIPT ≥1/150	462 407	10 635	13 312		7711	2143		2127	248	1544	17 000	772	688	12
NIPT ≥1/1000—no direct IPD	462 407	45 316	13 312		34 128	9487		0	664	432	23 231	826	601	3
NIPT ≥1/500—no direct IPD	462 407	26 357	13 312		20 762	5772		0	649	422	19 506	807	587	3
NIPT ≥1/150—no direct IPD	462 407	10 635	13 312		9678	2690		0	615	400	16 403	765	556	3