Table 4.
Incremental costs and outcomes compared with current pathway (in screening population of 698 500 pregnant women), using national data
| Testing strategy | Per 698 500 pregnant women (95% uncertainty interval) | ||||
|---|---|---|---|---|---|
| Incremental DS positive NIPT or IPD | Incremental DS confirmed by IPD | IPD avoided | IPD related miscarriage avoided | Incremental costs* (£000) | |
| NIPT ≥1/1000 | 256 (12 to 529) | 155 (−137 to 446) | 3319 (2436 to 4252) | 16.6 (7.1 to 30.5) | 6783 (824 to 17 096) |
| NIPT ≥1/500 | 237 (−10 to 557) | 141 (−130 to 443) | 3334 (2378 to 4225) | 16.7 (7.1 to 30.8) | 3058 (−482 to 8969) |
| NIPT ≥1/150 | 195 (−34 to 480) | 111 (−135 to 356) | 3368 (2779 to 4027) | 16.8 (7.4 to 30.4) | −46 (−1802 to 2661) |
| NIPT ≥1/1000—no direct IPD | 249 (−12 to 511) | 24 (−252 to 287) | 5079 (4271 to 5901) | 25.4 (11.5 to 45.4) | 6186 (−210 to 16 983) |
| NIPT ≥1/500—no direct IPD | 230 (−49 to 523) | 10 (−254 to 280) | 5094 (4273 to 5894) | 25.5 (11.7 to 45.9) | 2460 (−1565 to 8950) |
| NIPT ≥1/150—no direct IPD | 187 (−52 to 427) | −21 (−253 to 200) | 5128 (4405 to 5881) | 25.6 (11.7 to 46.2) | −643 (−3025 to 2822) |
DS=Down’s syndrome; IPD=invasive prenatal diagnosis; NIPT=non-invasive prenatal testing.
*At NIPT test costs £250.