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. 2016 Jul 6;6:29489. doi: 10.1038/srep29489

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(A) Acute application of 5 μM 4-AP in cerebellar slices from SCA6^84Q/84Q and WT mice. (B) Representative traces from SCA6^84Q/84Q mouse Purkinje cell before (orange, top) and after (red, bottom) 4-AP wash-in. (C) Purkinje cell spiking becomes more regular with the application of 4-AP (CV was reduced after 4-AP application, CV_before = 0.15 ± 0.02; CV_after = 0.10 ± 0.009; paired Student’s t test, P = 0.0027; N = 11), while (D) not altering firing rate (frequency_before = 60.7 ± 5.6 Hz; frequency_after = 61.8 ± 5.6 Hz; P = 0.15). ***P < 0.005.