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. 2016 Jul 6;6:29502. doi: 10.1038/srep29502

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Copyright © 2016, Macmillan Publishers Limited

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The N-terminus and helix α1 are shown as the green surface, while helices α2 to α5 in sky blue and helices α6 to α8 in deep blue, and helix α9 is represented by yellow ribbon. After displaced by tBid from the groove formed by helices α2 to α5, helix α9 loses helicity in the cytosol but then folds back within the MOM. The formation of the intersected and parallel α9 dimers attracts different anionic lipids to the vicinity as indicated, which may increase membrane tension and curvature, thereby promoting proteolipidic pore formation to release cytochrome c.