| a. Up-regulated pathways |
|
Granulocyte Adhesion and Diapedesis |
1.18E01 |
1.1E-01 |
CCL3,IL1B,MMP12,EZR,CCL20,CLDN4,CCL3L1/CCL3L3,SELE,MMP13,CXCL2,VCAM1,CXCL8, CXCR4, IL18, IL1RN,TNF,CXCR2,ICCL4,XCL1 |
|
Agranulocyte Adhesion and Diapedesis |
1.13E01 |
1.04E-01 |
CCL3,IL1B,MMP12,EZR,CCL20,CLDN4,CCL3L1/CCL3L3,SELE,MMP13,CXCL2,VCAM1,CXCL8, CXCR4,IL18,IL1RN,TNF,CXCR2,IL1A,CCL4,XCL1 |
|
Glucocorticoid Receptor Signaling |
1.11E01 |
7.69E-02 |
HSPA2,NFKB1,CCL3,CSF2,JAK2,IL1B,PLAU,SELE,NFKBIE,NFATC1,NFKBIA,VCAM1,CXCL8, FOS,IL1RN,DUSP1,SGK1,NR3C1,TNF,SMAD3,CDKN1A,IL10,FOXO3 |
|
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F |
1.07E01 |
3.91E-01 |
CCL3,CSF2,IL1B,TNF,IL1A,IL17A,IL10,CCL4,IL17F |
|
Communication between Innate and Adaptive Immune Cells |
1.01E01 |
1.25E-01 |
CCR7,CCL3,CSF2,IL1B,CCL3L1/CCL3L3,CD40,CXCL8,CD83,IL18,IL1RN,TNF,IL1A,IL10,CCL4 |
|
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F |
1.01E01 |
4.44E-01 |
CCL3,CSF2,IL1B,TNF,IL17A,IL10,CCL4,IL17F |
|
Hepatic Fibrosis/Hepatic Stellate Cell Activation |
9.55E00 |
1.03E-01 |
CCR7,NFKB1,IL1B,EDNRB,MMP13,CD40,VCAM1,CXCL8,IFNGR1,TNF,SMAD3,IL1A,EDN1,IL4R, IL10,TIMP |
|
IL-10 Signaling |
9.48E00 |
1.54E-01 |
FOS,IL18,NFKB1,IL1RN,IL1B,SOCS3,TNF,IL1A,IL4R,IL10,NFKBIE,NFKBIA |
|
T Helper Cell Differentiation |
9.41E00 |
1.67E-01 |
GATA3,IFNGR1,BCL6,IL18,STAT4,TNF,ICOSLG/LOC102723996,IL17A,IL4R,IL10,CD40,IL17F |
|
Atherosclerosis Signaling |
9.4E00 |
1.08E-01 |
NFKB1,IL1B,SELE,MMP13,CD40,VCAM1,CXCL8,CXCR4,IL18,IL1RN,TNF,IL1A,F3,TNFRSF12A, PLA2G4A |
| b. Down-regulated pathways |
|
PXR/RXR Activation |
2.28E00 |
2.17E-02 |
ABCC2, CPT1A |
|
FXR/RXR Activation |
2.07E00 |
1.82E-02 |
ABCC2, MTTP |
|
Mitochondrial L-carnitine Shuttle Pathway |
1.57E00 |
4.55E-02 |
CPT1A |
|
Granulocyte Adhesion and Diapedesis |
1.49E00 |
1.1E-02 |
CCL24, PECAM1 |
|
Agranulocyte Adhesion and Diapedesis |
1.44E00 |
1.04E-02 |
CCL24, PECAM1 |
|
LPS/IL-1 Mediated Inhibition of RXR Function |
1.31E00 |
8.16E-03 |
ABCC2, CPT1A |
|
Complement System |
1.28E00 |
2.86E-02 |
C4BPA |
|
Erythropoietin Signaling |
9.87E-01 |
1.27E-02 |
CBL |
|
Chemokine Signaling |
9.75E-01 |
1.33E-02 |
CCL24 |
|
Ephrin B Signaling |
9.46E-01 |
1.22E-02 |
CBL |
