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. 2016 Jul 5;17:150. doi: 10.1186/s13059-016-1011-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Single-cell WGBS is an accurate and reproducible method for genome-wide 5mC analysis. a 5mC promoter methylation status of 58 liver-specific genes. b Merged single cells have the same methylation pattern as their corresponding bulk. Each comparison is based on 10,000 randomly chosen 3-kb windows indicates the number of single cells sequenced. c Principal component analysis of single cells and bulk shows separate clustering of fibroblasts and hepatocytes (both panels) and hepatocytes from old and hepatocytes from young mice