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. 2016 Jul 5;17:146. doi: 10.1186/s13059-016-1013-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Hypo-enhancers have a unique epigenetic environment. a–f Profiles of Atac-Seq, Mnase-Seq, H3K4me2/3, H3K27me3, and Pol II ChIP-Seq over hypo- and hyper-enhancers. The enrichment (y-axis) of the various epigenetic marks is plotted over a region of 4 kb up- and downstream of the middle points of the two enhancer types