Image 2.
A, Flow cytometric analysis of bone marrow aspirate material shows a small number of a CD34+ cell population (0.6%). Of the CD34+ cells, there are markedly reduced stage I hematogones (normal precursor B cells) (arrowheads). The CD34 myeloid precursors (arrows) show increased expression of CD117, CD123, and CD13 and decreased expression of CD38, as expressed by the mean fluorescence intensity (MFI). The median and two standard deviation of normal MFI are 4,100 (1,120-5,920) for CD117, 25,020 (19,100-39,400) for CD38, 649 (240-1,080) for CD123, and 1,870 (920-3,300) for CD13. B, A normal bone marrow of an age-matched individual is shown for comparison.