. 2016 Jun 23;7(10):1273–1280. doi: 10.7150/jca.15035

Table 1.

Stratification analyses of the hOGG1 Ser326Cys polymorphism with regard to cancer susceptibility.

Variables	n	Dominant model (SerCys&CysCys versus SerSer)		Recessive model (CysCys versus SerSer&SerCys)		Homozygote comparison (CysCys versus SerSer)		Additive model (Cys allele versus Ser allele)
		OR (95% CI)^a	P^b	OR (95% CI)^a	P^b	OR (95% CI)^a	P^b	OR (95% CI)^a	P^b
Total	162	1.053 (1.009, 1.099)	0.018	1.108 (1.043, 1.178)	0.001	1.135 (1.055, 1.220)	0.001	1.059 (1.024, 1.095)	0.001
Cancer types
biliary tract	5	0.961 (0.776, 1.190)	0.717	1.379 (0.920, 2.068)	0.120	1.271 (0.867, 1.864)	0.219	1.064 (0.909, 1.245)	0.441
bladder	12	0.994 (0.874, 1.131)	0.928	1.102 (0.811, 1.497)	0.534	1.140 (0.872, 1.491)	0.337	1.028 (0.920, 1.149)	0.628
breast	16	1.006 (0.943, 1.072)	0.867	1.078 (0.993, 1.171)	0.074	1.080 (0.973, 1.198)	0.146	1.025 (0.974, 1.078)	0.347
colorectal	18	1.144 (0.992, 1.318)	0.064	1.142 (0.950, 1.373)	0.158	1.242 (0.985, 1.566)	0.067	1.126 (1.008, 1.258)	0.035
endometrial	5	1.270 (0.932, 1.732)	0.131	1.079 (0.623, 1.870)	0.785	1.132 (0.640, 2.004)	0.670	1.195 (0.918, 1.554)	0.185
esophageal	7	0.998 (0.867, 1.149)	0.981	1.146 (0.802, 1.637)	0.456	1.122 (0.797, 1.581)	0.509	1.028 (0.915, 1.154)	0.642
gastric	15	0.924 (0.799, 1.069)	0.290	1.043 (0.813, 1.338)	0.740	0.966 (0.754, 1.237)	0.782	0.984 (0.862, 1.125)	0.818
head and neck	15	1.055 (0.870, 1.280)	0.584	1.156 (0.907, 1.472)	0.241	1.219 (0.869, 1.711)	0.251	1.060 (0.910, 1.234)	0.455
hepatocellular	3	1.402 (0.756, 2.601)	0.283	1.254 (0.572, 2.748)	0.572	1.653 (0.581, 4.701)	0.346	1.186 (0.754, 1.865)	0.460
leukemia	4	1.385 (0.917, 2.090)	0.121	1.884 (1.021, 3.476)	0.043	2.044 (0.926, 4.515)	0.077	1.444 (1.032, 2.021)	0.032
lung	36	1.073 (0.984, 1.170)	0.110	1.098 (0.983, 1.225)	0.097	1.128 (0.989, 1.288)	0.074	1.064 (0.994, 1.139)	0.073
pancreatic	4	1.084 (0.929, 1.265)	0.307	0.880 (0.683, 1.133)	0.320	0.876 (0.666, 1.151)	0.342	0.993 (0.889, 1.109)	0.899
prostate	8	1.130 (0.891, 1.432)	0.315	1.111 (0.666, 1.851)	0.687	1.198 (0.669, 2.146)	0.543	1.119 (0.889, 1.408)	0.338
others	14	0.973 (0.839, 1.128)	0.712	1.131 (0.909, 1.407)	0.271	1.132 (0.885, 1.447)	0.322	1.022 (0.913, 1.143)	0.710
Ethnicities
Asian	74	1.060 (0.996, 1.129)	0.068	1.101 (1.023, 1.185)	0.010	1.129 (1.032, 1.235)	0.008	1.057 (1.012, 1.105)	0.013
Caucasian	75	1.075 (1.003, 1.153)	0.041	1.221 (1.075, 1.388)	0.002	1.257 (1.090, 1.450)	0.002	1.096 (1.030, 1.165)	0.004
mixed	12	0.940 (0.875, 1.010)	0.090	0.872 (0.740, 1.028)	0.102	0.856 (0.719, 1.020)	0.082	0.938 (0.882, 0.998)	0.043
African	1	1.280 (0.884, 1.852)	0.191	0.823 (0.281, 2.404)	0.721	0.891 (0.303, 2.619)	0.834	1.187 (0.859, 1.640)	0.300
Source of control
population	85	1.026 (0.968, 1.087)	0.389	1.075 (0.995, 1.161)	0.067	1.097 (0.996, 1.208)	0.061	1.035 (0.990, 1.083)	0.131
hospital	75	1.087 (1.018, 1.161)	0.013	1.152 (1.043, 1.272)	0.005	1.186 (1.060, 1.327)	0.003	1.088 (1.032, 1.147)	0.002
family	2	1.076 (0.879, 1.319)	0.476	0.985 (0.645, 1.504)	0.945	1.017 (0.655, 1.579)	0.941	1.050 (0.884, 1.246)	0.579
Sample size
large than 500	80	1.026 (0.980, 1.074)	0.270	1.080 (1.014, 1.151)	0.017	1.091 (1.007, 1.182)	0.033	1.035 (0.998, 1.073)	0.064
less than 500	82	1.099 (1.005, 1.202)	0.039	1.203 (1.046, 1.383)	0.010	1.248 (1.073, 1.450)	0.004	1.104 (1.028, 1.186)	0.007
HWE^c
yes	132	1.073 (1.025, 1.123)	0.002	1.118 (1.053, 1.187)	0.000	1.153 (1.074, 1.239)	0.000	1.070 (1.034, 1.109)	0.000
no	30	0.962 (0.857, 1.080)	0.513	1.103 (0.886, 1.373)	0.380	1.080 (0.842, 1.385)	0.544	1.002 (0.905, 1.108)	0.973

Note: ^a Random-effect model; ^b P value of effect for genetic variants; ^C Hardy-Weinberg equilibrium.