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. Author manuscript; available in PMC: 2016 Jul 6.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2015 Jul 26;93(3):588–596. doi: 10.1016/j.ijrobp.2015.07.2275

Figure 3. Histological evidence of vascular damage and decreased tumor cell density in 4T1 tumor tissue following combined CYT-6091 and radiation therapy.

Figure 3

A) Representative H&E images from treatment groups at time of tissue harvest. At day 1, tumor tissue from CYT-6091 and combined therapy groups displays marked vascular hemorrhaging. B) By day 7, tumor cell density in the combined treatment group is markedly reduced. C) Representative digitalized and binarized H&E images from treatment groups at day 7. D) Symbols above bars indicate significant differences resulting from post-hoc statistical tests. Data represent mean number of nuclei ± SEM (#, p<0.05).