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. 2016 Mar 11;23(1):25–32. doi: 10.1159/000443553

Fig. 1.

Fig. 1

Fig. 1

Fig. 1

Levels of MMP, ERK and β-catenin. a MMP-2 expression in pain (+) and no pain (-) animals on days 21 and 28 post cSCI. b Zymogram showing MMP-9 and MMP-2 activity on days 21, 35 and 42 following cSCI. c Western blots showing total extra cellular signaling kinase ERK1/2 in epicenter (bottom row); phospho-ERK1/2 (top row) following cSCI. Ratios of phospho-ERK1/2:total ERK1/2 shown graphically. d ERK1/2 is activated in animals with chronic pain on days 21 and 28 post cSCI. At day 42, the levels of ERK1/2 activation decreases to those similar to that of no pain animals. Graphical quantification of phospho-ERK1/2:total ERK1/2 also shown. e SCI increases β-catenin levels after 21 days with peak levels at day 42 as compared to sham. Quantitation of β-catenin also shown graphically. f β-Catenin expression in epicenter (1-5) and rostral region (6-10) of spinal cord following injury in TH(+) animals. 1-10 denote individual animal samples. Samples were run in duplicate (R1 = replicate 1, R2 = replicate 2).