Table 8. Suramin binding residues in nine non-homologous proteins from the PDB database: Interactions sorted based on the distance.

R/A/LA/D: Residue number/Atom of the residue/Atom of ligand/distance between the interacting atoms (in Å). For example, ‘LYS53/NZ/O80/2.6’ means that the atom NZ from Lys53 is at 2.6 Å from the O80 of the suramin drug in PDBid:1Y4LB. The non-specific binding of suramin to phospholipase A2-like proteins (PLA2) is demonstrated by different binding sites for the homologous PLA2-X and PLA2-Z. Also, suramin binds to different sites even within the homologous subunits of PLA2-Y (marked with asterisks).

PDBid	R/A/LA/D	R/A/LA/D	R/A/LA/D	R/A/LA/D
1Y4LB,PLA2-X 3BJWA,PLA2-Y* 3BJWB,PLA2-Y* 4YV5A,PLA2-Z	LYS53/NZ/O80/2.6 PHE124/CD2/O4/2.6 SER21/OG/O25/2.7 ASN114/ND2/O35/2.7	LYS69/NZ/O54/2.8 TRP125/O/O29/3.0 SER17/OG/N19/2.8 LYS116/NZ/O35/2.7	TYR52/CD2/C60/2.8 LYS127/N/O30/3.4 LYS115/NZ/O36/2.8 TYR121/CD2/N44/3.1	ARG34/CD/C70/2.9 PRO36/CD/O28/3.5 LYS16/NZ/O34/2.8 LYS115/C/O23/3.3
1Y8EA 2H9TH 2NYRB 3GANA 3PP7B 3UR0B 4J4VA 4X3UB	ARG244/NH1/O23/2.7 GLU247/N/O77/2.5 TYR255/OH/O45/2.6 PRO152/O/N44/2.8 LYS335/NZ/O84/3.1 ARG413/NE/O84/2.7 THR63/O/N53/2.7 SER40/O/N63/2.6	LYS241/NZ/O24/2.7 ARG93/NE/O35/3.0 TYR102/OH/O30/2.8 ASP151/O/N41/3.0 ASN51/ND2/O81/3.1 PRO39/O/O79/2.8 ASN66/N/O78/2.9 HIS47/NE2/O23/2.8	LYS214/NZ/O84/2.7 ARG101/NE/O36/3.0 ARG105/NH2/O29/2.9 TYR48/OH/N53/3.0 THR26/OG1/O80/3.1 TRP42/NE1/O84/3.3 LYS67/NZ/O77/3.1 ARG20/NH1/O86/2.8	LYS220/NZ/O78/2.7 ASP243/O/N44/3.3 ARG71/NE/O23/3.0 GLY79/O/O54/3.8 GLY331/N/O82/3.3 ALA41/N/O79/3.3 GLU94/O/O85/3.4 TRP42/NE1/O81/3.0