Table 5.

Expression of interferons and interferon-stimulated genes according to exacerbation number during the last 12 months

Genes	Healthy subjects (n=35)	COPD <2 exacerbations (n=40)	COPD ≥2 exacerbations (n=10)	P-value
IL-29	0 (0–256)	0 (0–435)	0 (0–242)	0.633
IFN-β	0 (0–56)	0 (0–557)	0 (0–131)	0.270
MxA	9,979 (1,572–27,126)	9,320 (1,489–68,816)	5,022 (0–26,672)	0.100
OAS	960 (0–2,393)	646 (0–3,072)	423** (0–900)	0.006
Viperin	444 (0–2,163)	857** (0–68,346)	362 (0–19,218)	0.002

Notes: Data are presented as median (range) copy number per µL of cDNA for each gene of interest. P-values indicate Kruskall–Wallis test;

^**P<0.01 vs healthy subjects.

Abbreviations: IL-29, interferon lambda1; IFN-β, interferon beta.