Table 1.

Selected articles on preeclampsia-eclampsia (PE-E).

Reference	Rationale	Methodology	Outcomes	Results
[1]	Low-dose aspirin eligibility.	Mathematical modeling.	Minimum control event rate. Minimum event rate for treatment. Threshold number needed to treat.	Moderately-elevated-risk patients are eligible for low-dose aspirin.
[2]	Management guidelines.	-	-	Synopsis of the 2014 Australia and New Zealand PE-E management guidelines.
[3]	Congo red dot (CRD) urine test is a rapid, affordable diagnostic test.	Prospective cohort.	First, second, and third trimester PE detection.	In the first trimester CRD used alone detects 33.3%, 16.1%, and 20% of early, late, and all PE cases.
[5]	Contextualizes significance of fullPIERS.	-	-	fullPIERS offers PE-E prediction.
[6]	Historic context for maternal severe hypertension care bundle development.	Review article.	Vital signs changes. Systolic blood pressure (SBP), diastolic blood pressure (DBP).	Eclampsia alarm criteria: increases from pregnancy baseline––doubled maternal pulse pressure, SBP by 64 ± 12 mm Hg, or DBP by 31 ± 10 mm Hg.
[7]	Historical context.	-	-	Defined early- and late-onset PE-E.
[9]	California pregnancy-related deaths, 2002–2005. In the US in 1997, maternal mortality rate was 7.7/100,000 live births. By 2009 the rate increased to 17.8/100,000.	Retrospective cohort.	Leading causes of maternal mortality.	Cardiovascular disease, PE-E, hemorrhage, venous thromboembolism, and amniotic fluid embolism accounted for 143 of 207 pregnancy-related maternal deaths from 2002–2005.
[13]	Relevance of continuous quality improvement in women’s healthcare.	-	-	Work with precursors, processes, and indicators to deliver better population health and better healthcare at lower cost.
[14]	Combined antepartum low-dose aspirin and heparin.	Systematic review and meta-analysis.	Incidence of PE, severe PE, early-onset PE, and small for gestational age (SGA) fetuses.	In early-onset PE, low molecular weight heparin in combination with low-dose aspirin offers further reduction of PE and SGA fetuses than use of low-dose aspirin alone.
[16]	Anticonvulsant efficacy for PE-E.	Systematic review of randomized trials of anticonvulsants with or without a placebo control group.	Eclampsia prevention. There was insufficient evidence to compare magnesium sulfate to diazepam, isosorbide, or methyldopa.	Risk of eclampsia is halved by magnesium sulfate, which is more effective than phenytoin and nimodipine. However, magnesium sulfate increases the risk of cesarean delivery when compared to phenytoin.
[18]	Preeclampsia admitting diagnosis patients at a single-tertiary perinatal unit.	24 month pre- and 41 month post-intervention cohort comparison. Intervention was a standardized surveillance protocol.	Any of 17 adverse maternal outcomes and any of seven adverse perinatal or infant outcomes.	Adverse maternal outcomes fell from 5.1% to 0.7%, Fisher p < 0.001, odds ratio 0.14, 95% confidence interval 0.04–0.49. Unchanged perinatal outcomes.
[28]	Medical management of severe hypertension	-	-	Severe hypertension treatment protocol.