Mice (5/grp) were immunized with either PBS, rH1CA + GLA-SE, or rH5VN + GLA-SE, and serum collected on day 42 was assayed for cross-inhibitory Abs by HAI. The viruses tested included clade 1 viruses A/Vietnam/1194/2004 (H5N1) (panel a) and A/Cambodia/RO405050/2007 (H5N1) (panel b), clade 2.2 virus A/turkey/Turkey/1/2005 (H5N1) (panel c), clade 2.3.4 virus A/H5N1/Anhui/1/05 (H5N1) (panel d), or the H1N1 virus A/California/07/09 (H1N1) (panel e).