Figure 4. MAb-mediated protection against a lethal challenge of H5N1 virus in mice.
CD1 mice (6/grp) were injected with either PBS (black line) or 5 mg kg-1 of MAb 808k (blue line, open diamonds) or MAb 24415k (red line, open circles). Animals were challenged 12 hours later with 10 LD50 A/Vietnam/1194/2004 (H5N1) virus and then monitored for the next 14 days. Panel A: average weight gain. Panel B: Survival kinetics.