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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Kidney Int. 2016 Mar 24;90(1):67–76. doi: 10.1016/j.kint.2016.01.022

Figure 1. Severity of AKI without and with single or combined FeS/SnPP pre-treatment.

Figure 1

Left panel: Neither test agent alone induced significant protection against maleate- induced AKI. Conversely, when used together, marked protection against AKI resulted (p values vs. maleate alone). The horizontal lines represent mean BUN and creatinine concentrations for normal mice.

Right panel: Ischemia-reperfusion induced marked BUN and creatinine increases which were significantly reduced by either SnPP or FeS+SnPP pre-treatment. (p values vs. I/R alone). The degree of protection was modestly greater with combined pre-treatment, as judged by lower plasma creatinine concentrations (0.53 ± 013 vs. 038 ±0.06 mg/dl; SnPP vs FeS+SnPP, respectively; <0.05).