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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Kidney Int. 2016 Mar 24;90(1):67–76. doi: 10.1016/j.kint.2016.01.022

Figure 10. SnPP administered at the time of maleate injection mitigates prior FeS/SnPP mediated preconditioning and resistance to ARF.

Figure 10

Either unconditioned (control) mice or FeS+SnPP preconditioned (PC) mice were challenged with maleate. Immediately following maleate injection, the preconditioned mice were either left alone (n,6), or they received a second SnPP dose (n, 10). Eighteen hrs later, AKI severity was assessed. The preconditioned mice showed marked protection against AKI, but the administration of a second dose of SnPP at the time of maleate injection negated a large part of the preconditioning cytoprotective effect. This supports the concept that increased HO-1 activity is mechanistically involved in the emergence of the cytoresistant state.