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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Kidney Int. 2016 Mar 24;90(1):67–76. doi: 10.1016/j.kint.2016.01.022

Figure 5. Renal cortical haptoglobin mRNA and protein levels following FeS / SnPP administration.

Figure 5

Each test agent increased haptoglobin mRNA, and at 18 hrs, a synergistic increase was observed (left hand panel). As shown in the right hand panel, progressive haptoglobin protein elevations developed, reaching 5 fold greater than control levels at the 18 hr time point. Of note, the haptoglobin protein levels varied considerably and followed a non parametric distribution. Hence, they were analyzed vs. control values by Wilcoxon rank sum test. Not shown, renal cortical haptoglobin and plasma haptoglobin levels were tightly correlated (r, 0.92), indicating that plasma haptoglobin levels could potentially serve as a biomarker for renal haptoglobin gene induction.