FIG 8.

Neutralizing antibody responses to SF162 during challenge phase parts 1 and 2. TZM-bl assay neutralization data 5 weeks before a challenge (0 wk); 9, 17, and 21 weeks after the first challenge with microbicide; 1 week after the 12 challenges without microbicide (week 42); and 5 weeks thereafter (week 47). Each symbol represents one animal. Colors are indicative of the times when infection was detected by plasma viremia as follows: red, during the first 6 challenges (until week 9 postchallenge); blue, during challenges 7 to 12 (weeks 11 to 21 postchallenge); black, during challenges 13 to 24 (from week 22, in the absence of microbicide). Empty symbols represent animals that were not infected. The mean of each group is indicated by a solid line. For V+M versus V, P < 0.0001 (Mann-Whitney test).