FIG 5.
Cellular pathways of BTV8wt- and BTV8ΔNS4-infected cells. (A to C) Canonical cellular pathways were analyzed using Ingenuity Pathway Analysis. Only canonical pathways with a P value of <6.3 × 105 are shown. The ratios correspond to the number of genes found DE in a given pathway divided by the total number of genes contained in that pathway. A specific pathway is colored in orange or blue depending on whether it has been predicted to be activated (positive Z-scores) or inhibited (negative Z-scores), respectively. The gray bars represent pathways where no prediction can currently be made. PRR, pattern recognition receptors; AII, antiviral innate immunity; DC, dendritic dell; MΦ, macrophages; EC, endothelial cells; RA, rheumatoid arthritis; GC, gastric cells; NKC, natural killer cells; AR, antiviral response; OSR, oxidative-stress response; DM, diabetes mellitus. (A) BTV8ΔNS4- versus mock-infected cells. (B) BTV8wt- versus mock-infected cells. (C) BTV8ΔNS4- versus BTV8wt-infected cells.