Table 2.
GWAS in IgAN: populations studied and significant associations
| Feehally [21], 2010 | Gharavi [22], 2011 | Yu [23], 2012 | Kiryluk [24], 2014 | |
|---|---|---|---|---|
| Discovery | 431 European | 1,194 Chinesea | 1,434 Chinese | 1,194 Chinesea |
| cohort | 1,553 European (Italy, USA, France) | |||
| Replication | – | 712 Chinese | 2,703 Chinese | 2,046 Chinese |
| cohort | 1,238 European (Italy, USA) | 445 Japanese | ||
| 2,420 European (UK, France, Germany, Italy, Czech Republic, Hungary, Turkey, Poland) | ||||
| Significant | 6p21 HLA (multiple) | 6p21 HLA (multiple) | 6p21 HLA (multiple) | 6p21 HLA (multiple) |
| associations | 6p21 TAP1/PSMB8 | – | 6p21 TAP1/PSMB8 (Asian only) | |
| – | 1q32 CFHR1/3 | – | 1q32 CFHR1/3 | |
| – | 22q12 HORMAD2 | – | 22q12 HORMAD2 | |
| – | – | 17p13 TNFSF13 | 17p13 TNFSF13 | |
| – | – | 8p23 DEFA | 8p23 DEFA (Asian only) | |
| 6p11 ITGAM-ITGAX | ||||
| 1p13 VAV3 | ||||
| 9q34 CARD9 | ||||
The studies are listed as first author [ref.], year.
a
The Chinese discovery cohort was the same in these studies.