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An algorithm of recommended treatment options for IgAN. Modified from Lai [60] and used with permission. Broken lines denote less frequently encountered scenarios. Rx = Treatment. a Therapy with efficacy-of-evidence base grade 1 data. b Therapy with high a priori evidence to use but not tested independently in RCT. c There is no evidence that immunosuppressive drugs can benefit declining function in patients starting therapy with >50% loss in GFR.
