Table 2.

Multivariable association of incident atrial fibrillation with risk of ESRD among participants with CKD in the Chronic Renal Insufficiency Cohort Study

Statistical Approach	N/Rate (Per 100 person-yr) of ESRD Events	Hazard Ratio (95% Confidence Interval) of AF with ESRD
Cox regression model
No incident AF	581/3.4	Reference
Incident AF	43/11.8	3.3 (2.4 to 4.6)
Marginal structural model
No incident AF	581/3.4	Reference
Incident AF	43/11.8	3.2 (1.9 to 5.2)

Adjusted for demographics, clinical site, proteinuria, eGFR, tobacco use, heart failure, coronary heart disease, hypertension, diabetes, systolic BP, body mass index, hemoglobin, diuretic use, and angiotensin converting enzyme (ACE) inhibitor/angiotensin receptor blocker (ARB) use. AF, atrial fibrillation.