Table 2. Significant association loci.
Chr | Start | End | Range | Trait | rsID | P-value | MAF | ES | ω2 | Analyses | Candidate genes |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 187.4 | 187.6 | 0.2 | LVIDd | rs32292745 | 2.97E-06 | 0.08 | 0.21 | 1% | 1dLVIDd | Lyplal1 |
3 | 82.1 | 82.6 | 0.5 | FS | rs32712632 | 9.06E-07 | 0.3 | 6.1 | 14% | 3FS | Tdo2, Accn5, Gucy1a3 |
3 | 94.3 | 95.7 | 1.4 | LVIDd | rs33064660 | 1.30E-06 | 0.22 | 0.29 | 7% | 3LVIDd | Rorc, Oaz3, Mrpl9, Snx27*, Selenbp1, Psmd4, Tmod4, Gm128, Bnipl, Anxa9, Lass2, Ctsk, Golph3l, Ecm1, Prpf3, Mrps21, Gm129, BC028528, Car14 |
4 | 54.2 | 55 | 0.8 | LVM | rs27794497 | 9.30E-07 | 0.36 | 18.2 | 11% | 3LVM,3dLVM,1LVM,1dLVM | Klf4 |
4 | 58.2 | 58.3 | 0.1 | LVIDd | rs27851114 | 2.78E-06 | 0.06 | 0.2 | 6% | 1dLVIDd | Txndc8, Svep1, Musk |
4 | 62.4 | 62.7 | 0.3 | LVM | rs28295600 | 3.77E-06 | 0.39 | 18.2 | 9% | 3LVM | Rgs3, Zfp618, Orm3, Whrn |
4 | 63.7 | 64 | 0.3 | LVM | rs3656076 | 1.74E-07 | 0.44 | 20.8 | 8% | 3LVM,3dLVM | Tnc |
4 | 93.1 | 95.2 | 2.1 | IVSd | rs28128253 | 4.65E-09 | 0.36 | 0.10 | 15% | 1IVSd | Jun |
7 | 51.5 | 52.4 | 0.9 | LVM | rs40560913 | 1.44E-09 | 0.4 | 18.8 | 10% | 3LVM,3dLVM,2LVIDd,iLV,dLV | Myh14, Izumo2* |
9 | 66.9 | 69.6 | 2.7 | IVSd | rs49424819 | 7.35E-07 | 0.35 | 0.09 | 1% | 1dIVSd | M5C1000I18Rik, Vps13c |
9 | 74.9 | 75.8 | 0.9 | FS | rs33896682 | 3.41E-06 | 0.40 | 3.22 | 4% | 2dFS | Arpp19*, Bmp5 |
9 | 75.8 | 80.2 | 4.4 | IVSd | rs13480288 | 1.95E-09 | 0.38 | 0.10 | 12% | 1dIVSd | Tinag, Lrrc1*, Omt2b, Impg1 |
9 | 84 | 84.6 | 0.6 | IVSd | rs36266287 | 6.89E-07 | 0.38 | 0.09 | 6% | 1dIVSd | Bckdhb, Fam46a |
11 | 36.8 | 36.9 | 0.1 | LVIDd | rs6333970 | 2.83E-06 | 0.31 | 0.25 | 8% | 1LVIDd | Tenm2 |
12 | 57.8 | 57.9 | 0.1 | LVIDd | rs47048438 | 3.41E-06 | 0.07 | 0.20 | 1% | 1dLVIDd | Nkx2-9, Slc25a21* |
15 | 40 | 40.1 | 0.1 | FS | rs48791248 | 2.71E-07 | 0.10 | 6.79 | 14% | 1FS | Dpys, Lrp12, Zfpm2 |
18 | 47 | 49.2 | 2.2 | FS | rs51860788 | 1.04E-06 | 0.41 | 6.62 | 6% | 2FS | Trim36 |
Start and end positions as well as range are in the unit of Mb. Peak p-value and SNP rsID and are listed. If multiple SNPs have the same p-value, only one representative rsID is listed and indicated by an underline. MAF denotes the minor allele frequency. ES denotes the effect size per allele. The units for the effect sizes are mm for IVSd and LVIDd, mg for LVM, and % for FS. Variance explained is denoted by ω2. Analyses are the analyses in which the SNP exceeded the genome-wide significant threshold. If multiple analyses yielded significant p-value at a given SNP, the underlined analyses has the most statistically significant p-value. Candidate genes are denoted by structural variation (underlined), cis-eQTL (italics) and correlation with trait were present (bold). Golph3l and Bmp5 have a stop_gained variant. M5C1000I18Rik and Dpys have a splice acceptor variant. Dpys has 2 missense variants.
* denotes that one of the lead SNPs resided in the gene.