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. Author manuscript; available in PMC: 2016 Sep 9.
Published in final edited form as: J Am Chem Soc. 2015 Aug 27;137(35):11246–11249. doi: 10.1021/jacs.5b07203

Table 2.

Optimization of Asymmetric Reactionsa

graphic file with name nihms797607f3.jpg
a

Conditions: 1.0 equiv 4b, 1.2 equiv amine, 1.4 equiv LiOtBu, 4 mol % Pd(OAc)2, 10 mol % ligand, PhCF3 (0.1 M), 95 °C, 16 h.

b

The reaction was conducted in toluene solvent.