Table 3.

Asymmetric Synthesis of Aminoindanes^a

entry	substrate	amine	% yieldb	er
1 2c			98 95	>99:1 99:1
3	4b		88	95:5
4	4b		90	95:5
5	4b		47	89:11
6	4b		63	>99:1
7	4b		82	97:3
8			56	97:3
9	4c		59	>99:1
10			77	98:2

^aConditions: Reactions were conducted on a 0.1 mmol scale using 1.0 equiv 4, 1.2 equiv amine, 1.4 equiv LiO^tBu, 4 mol % Pd(OAc)₂, 10 mol % (S)-^tBu-PHOX, toluene (0.1 M), 95 °C, 3–16 h.

^bIsolated yields (average of two or more experiments).

^cThe reaction was conducted on a 1.0 mmol scale.