FIGURE 3.

Complementary gray scale and spectrally decomposed dual-energy CT images of control and apolipoprotein E–deficient (ApoE^−/−) mice before and after administration of a liposomal iodine contrast agent (red denotes iodine, green denotes calcium). Spectral decomposition permits more sensitive discrimination between plaque calcification and iodinated contrast. Arrows demonstrate colocalization of aortic plaque calcium and liposomal iodine taken up by plaque macrophages after blood pool clearance of liposomal iodine. (Reprinted with permission of (43).)