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. Author manuscript; available in PMC: 2016 Jul 6.
Published in final edited form as: J Nucl Med. 2015 Aug 13;56(10):1469–1475. doi: 10.2967/jnumed.115.160994

FIGURE 4.

FIGURE 4

(A) Representative T1-weighted MR images of abdominal aortas in apolipoprotein E–deficient mice fed high-cholesterol diets and treated with one of the following: intravenous saline (placebo), oral simvastatin (statin), reconstituted HDL nanoparticles (rHDL), or simvastatin-HDL nanoparticles ([S]-rHDL). Progressive aortic thickening was seen in all groups except those treated with [S]-rHDL (scale bar represents 1 mm). (B) Normalized wall indices ([outer wall area – lumen area]/outer wall area) from MR images, demonstrating the substantial therapeutic effect of targeted simvastatin delivery via [S]-rHDL (n = 8 per group). (Reprinted with permission of (48).)