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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Semin Immunol. 2016 Mar 11;28(2):197–204. doi: 10.1016/j.smim.2016.02.003

Figure 2.

Figure 2

Figure 2

Neutrophils make up a continuum of phenotypes. The tumor microenvironment can influence the polarization state of TANs. TGFβ can differentiate neutrophils toward a protumoral N2 phenotype. The exact origin of recruited neutrophils is still unknown. N1 TANs might originate from high-density circulating neutrophils, while N2 TANs emanate from immunosuppressive low-density neutrophils. Another alternative could be that the local tumor microenvironment dictates the fate of recruited neutrophils. On the contrary, TANs might be the origin of different circulating neutrophil populations.