Table 1.

Common clinical manifestations of cystic fibrosis in adults.

Sinopulmonary	Gastrointestinal	Endocrine	Renal	Psychiatric	Other
Chronic suppurative lung disease with airflow obstruction and bronchiectasis Allergic bronchopulmonary aspergillosis Pneumothorax Haemoptysis Respiratory failure with cor pulmonale and pulmonary hypertension Chronic sinusitis Nasal polyposis	Distal intestinal obstruction syndrome Constipation Intussusception Liver cirrhosis with portal hypertension Bowel cancer Pancreatic exocrine insufficiency Recurrent pancreatitis Gastrooesophageal reflux disease Fat soluble vitamin deficiency	CF related diabetes Delayed puberty Metabolic bone disease Oligomenorrhea	Nephrolithiasis Hyponatraemic hypochloraemic metabolic alkalosis Chronic kidney disease (CF diabetes, aminoglycoside exposure) Oxalate nephropathy	Depression Anxiety	Difficult vascular access Drug allergy CF arthropathy/ hypertrophic pulmonary osteoarthropathy