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. 2016 Jun 29;11:3035–3048. doi: 10.2147/IJN.S107292

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© 2016 Campos-Martorell et al. This work is published and licensed by Dove Medical Press Limited

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Simvastatin-loaded liposome characterization.

Notes: (A) Structure and composition of neutral liposome compounds used in detection experiments. (B) CryoTEM image of liposomes with simvastatin encapsulated formed by the lipid mixture DLPC/CHOL/CHOL–PEG (scale bar: 200 nm). (C–E) UHPLC chromatographic profile of peaks corresponding to (C) active simvastatin (also named acid simvastatin), (D) IS (simvastatin hydroxy acid ammonium salt), and (E) inactive simvastatin (also named lactone). For each compound analyzed, retention time (expressed in minutes) and transition are presented.

Abbreviations: CryoTEM, cryogenic transmission electron microscopy; DLPC, 1,2-didodecanoyl-sn-glycero-3-phosphocholine; CHOL, cholesterol; CHOL–PEG, cholesteryl–polyethylene glycol 600 sebacate; UHPLC, ultra-high-protein liquid chromatography; IS, internal standard; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; simv, simvastatin; min, minute; PEG, polyethylene glycol.