Table 1.

Liposome composition and characterization

Sample	Liposome lipid composition	Encapsulated	ζ potential (mV)	Mean size (nm)	PDI
LIP1+	DLPC 50%/CHOL 10%/CHOL–PEG 5%/CHOL (+) 35%	PBS	+30.17	157.57	0.12
LIP2=	DLPC 50%/CHOL 45%/CHOL–PEG 5%	PBS	+2.21	171.07	0.10
LIP3−	DLPC 50%/CHOL 45%/CHOL–PEG 5%/DOPA (−) 35%	PBS	−38.30	154.60	0.19
LIP4S	DLPC 50%/CHOL 45%/CHOL–PEG 5%	Simvastatin 6 mg/mL	−1.01	151.85	0.15

Abbreviations: PDI, polydispersity index; DLPC, 1,2-didodecanoyl-sn-glycero-3-phosphocholine; CHOL, cholesterol; CHOL–PEG, cholesteryl–polyethylene glycol 600 sebacate; PBS, phosphate-buffered saline; DOPA, 1,2-dioleoyl-sn-glycero-3-phosphoric acid monosodium salt.